Fig. 5: HOXA5 inhibits PCa growth in vivo. | Cell Death Discovery

Fig. 5: HOXA5 inhibits PCa growth in vivo.

From: TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signaling

Fig. 5: HOXA5 inhibits PCa growth in vivo.

Subcutaneous tumor growth in mice inoculated with HOXA5-overexpressed or silenced PC-3 cells. A Representative pictures of xenografted tumors derived from PC-3 cells. B Tumor volume was measured every 3 days. C The average weight of tumor mass in each group was shown. D IHC analysis of HOXA5, Ki-67 and CD133 in sections of xenografts. Images were taken at 400× and 600× magnifications, respectively. E The expression of HOXA5 and CSC markers (Nanog and Sox-2) in tumor tissues was detected by Western blot assay. *P < 0.05, **P < 0.01. Results were presented as mean ± SD of six animals per group.

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