Fig. 2: Distinct but contradictory molecular patterns of NMM and MM at bulk-seq resolution. | Cell Death Discovery

Fig. 2: Distinct but contradictory molecular patterns of NMM and MM at bulk-seq resolution.

From: Decoding the metastatic potential and optimal postoperative adjuvant therapy of melanoma based on metastasis score

Fig. 2: Distinct but contradictory molecular patterns of NMM and MM at bulk-seq resolution.The alternative text for this image may have been generated using AI.

A, B Volcano plot (A) and heatmap (B) showing the up-regulated genes in NMM and MM. C, D GO and KEGG analyses depicting the enriched pathways and biological function in MM (C) and NMM (D). E, F GSEA showing the enriched gene lists in MM (E) and NMM (F). G Different expression levels of four metastasis-related genes between MM and NMM. NMM non-metastatic melanoma, MM metastatic melanoma, bulk-seq bulk RNA sequencing, GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, GSEA gene set enrichment analysis. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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