Fig. 4: Predicting the metastatic potential and prognosis of melanoma by MET score. | Cell Death Discovery

Fig. 4: Predicting the metastatic potential and prognosis of melanoma by MET score.

From: Decoding the metastatic potential and optimal postoperative adjuvant therapy of melanoma based on metastasis score

Fig. 4: Predicting the metastatic potential and prognosis of melanoma by MET score.The alternative text for this image may have been generated using AI.

A Venn plot showing the common up-regulated genes in MM at bulk- and scRNA-seq levels. B Forest plot of four potential metastatic-related genes most related to the prognosis of melanoma screened by multivariate Cox regression analysis with a bootstrap algorithm. C Scatter plot showing the low and high MET score group in the TCGA-SKCM cohort. D Kaplan–Meier survival curves based on the MET score in the TCGA-SKCM cohort. E Validation of the prognosis prediction efficiency of the MET score in pan-cancers. F t-SNE plots showing the MET score in all cell types (upper panel), melanoma cells (middle panel), and macrophages (lower panel). MET score metastasis score, MM metastatic melanoma, bulk-seq bulk RNA sequencing, scRNA-seq single-cell RNA sequencing, t-SNE t-distributed stochastic neighbor embedding, TCGA-SKCM The Cancer Genome Atlas Skin Cutaneous Melanoma. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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