Fig. 7: A working model based on the current findings. | Cell Death Discovery

Fig. 7: A working model based on the current findings.

From: Nucleophosmin 1 cooperates with BRD4 to facilitate c-Myc transcription to promote prostate cancer progression

Fig. 7: A working model based on the current findings.

Left: NPM1 interacts with BRD4 to lead to BRD4 binding to the promoter of MYC gene to promote the MYC transcription, which in turn initiates the proliferation and invasion of PCa cells. Right: BET inhibitors block the interaction between NPM1 and BRD4 to stop the transcription of MYC gene to inhibit the PCa progression.

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