Fig. 6: Motor deficits and olfactory dysfunction in mice with transient chemogenetic inhibition of dopaminergic neurons in the SN. | Cell Death Discovery

Fig. 6: Motor deficits and olfactory dysfunction in mice with transient chemogenetic inhibition of dopaminergic neurons in the SN.

From: Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease

Fig. 6: Motor deficits and olfactory dysfunction in mice with transient chemogenetic inhibition of dopaminergic neurons in the SN.

a Schematic model of stereotaxic injection of virus in the SN. b Representative images of immunofluorescence staining of TH-positive cells (green) and AAV-EF1a-DIO-hM4Di-mCherry (hM4D) virus (red) (bar = 50 μm). c Representative images of paws’ print visualization in the Catwalk test. Duration (d) and speed (e) of mice crossing the monitoring area, stride length of all four paws (f) in the Catwalk test. (LF left front, LH left hind, RF right front, RH right hind). g Time to turn in the pole test. Representative images of track visualization in the olfactory discrimination test (h) and quantification of the accumulated duration in familiar compartments (i) of mice. (n = 9, *P < 0.05, **P < 0.01). Paired t test was applied.

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