Fig. 7: TFAM or NRF1 knockdown alleviates the effect of ZNF281 depletion on mitochondrial function. | Cell Death Discovery

Fig. 7: TFAM or NRF1 knockdown alleviates the effect of ZNF281 depletion on mitochondrial function.

From: ZNF281 inhibits mitochondrial biogenesis to facilitate metastasis of hepatocellular carcinoma

Fig. 7: TFAM or NRF1 knockdown alleviates the effect of ZNF281 depletion on mitochondrial function.The alternative text for this image may have been generated using AI.

A Measurement of OCR in ZNF281 and TFAM knockdown HLE cells. B Measurement of OCR in ZNF281 and NRF1 knockdown HLE cells. C Basal respiration, proton leak, and maximal respiration from (A) were quantified. D Basal respiration, proton leak, and maximal respiration from (B) were quantified. E, F Lactate release was determined in ZNF281 and TFAM knockdown HCC cells. G Lactate release was determined in ZNF281 and NRF1 knockdown HLE cells. *p < 0.05, **p < 0.01, and ***p < 0.001. All experiments were performed at least three times.

Back to article page