Fig. 3: An epithelia-specific enhancer within the LCE2 locus is activated during differentiation. | Cell Death Discovery

Fig. 3: An epithelia-specific enhancer within the LCE2 locus is activated during differentiation.

From: Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33

Fig. 3: An epithelia-specific enhancer within the LCE2 locus is activated during differentiation.

A ChIP-seq tracks of H3K27ac and Pol2 in keratinocytes (proliferating or differentiated). Enlarged areas of XP33 promoter, Enhacer 1 and Enhacer 2 are shown below. B Dense ChIP-seq tracks of H3K27ac in different cell types from ENCODE. C ChIP-seq tracks of CTCF and SMC1A in keratinocytes (proliferating or differentiated). D Dense ChIP-seq tracks of CTCF in different cell types from ENCODE. E XP33 expression from RNA-seq in cells derived from different types of epithelia. F ATAC-seq regions (top) and H3K27ac-HiChIP chromatin loops (bottom) in the same samples.

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