Fig. 8: Proposed mechanism by which RPLP2 regulates glycolytic reprogramming and HCC progression. | Cell Death Discovery

Fig. 8: Proposed mechanism by which RPLP2 regulates glycolytic reprogramming and HCC progression.

From: RPLP2 activates TLR4 in an autocrine manner and promotes HIF-1α-induced metabolic reprogramming in hepatocellular carcinoma

Fig. 8

RPLP2 is secreted into the extracellular space and binds to the TLR4 receptor by autocrine signalling, activating the downstream PI3K/AKT cascade reaction and upregulating the expression of HIF-1α and its entry into the nucleus. HIF-1α increases the transcription level of glycolysis-related enzymes and glucose transporters, promoting glycolytic reprogramming and HCC progression.

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