Fig. 7: CEP can activate Nrf2 for nuclear translocation. | Cell Death Discovery

Fig. 7: CEP can activate Nrf2 for nuclear translocation.

From: Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway

Fig. 7

A AGS/HGC27 cells were treated with 5, 10, and 15 μmol/L CEP for 48 h. The protein expression of HMOX1 was measured by western blot (n = 3). B AGS/HGC27 cells were treated with 5, 10, and 15 μmol/L CEP for 48 h. The protein expression of cyto-Nrf2 and nucl-Nrf2 was measured by western blot (n = 3). C The protein expression of Nrf2 in AGS/HGC27 cells silenced by siRNA (siRNA1, siRNA2, and siRNA3) was measured by western blot. D AGS/HGC27 cells were treated with 10 μmol/L CEP or siRNA3 for 48 h. The protein expression of Nrf2 and HMOX1 in AGS/HGC27 cells was measured by western blot. The data were expressed as means ± SD; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001, significantly different from the control group. #p < 0.05, ##p < 0.01, ###p < 0.001, and ####p < 0.0001, significantly different from the Negative-control-CEP group.

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