Fig. 6: piR-YBX1 inhibits tumor growth and lung metastasis of TNBC in vivo. | Cell Death Discovery

Fig. 6: piR-YBX1 inhibits tumor growth and lung metastasis of TNBC in vivo.

From: PIWI-interacting RNA-YBX1 inhibits proliferation and metastasis by the MAPK signaling pathway via YBX1 in triple-negative breast cancer

Fig. 6

A–C Influence of piR-YBX1 on the growth of TNBC cells-derived tumors in mice. Tumor images, growth curves and tumor weights are shown. D Fluorescence images of mice show the antimetastatic effects of piR-YBX1 in vivo (left) and value for total flux of the lung metastasis ROI (right) is shown. E Representative pictures of macro-metastasis nodules in the lungs after intravenous injection of tumor cells (left) and statistics analysis of the number of macro-metastasis nodules in the lungs (right). F Presentative H&E staining photos of lung metastasis between control and piR-YBX1 OE group (left) and the percentage of tumor area in total lung area which shows the degree of lung metastasis. Scale bar: 2.5 mm. G–I One week after the injection of MDA-MB-231 and BT549 BC cells, agopiR-YBX1 and agopiR-NC were injected into the tumors. Tumor images, growth curves and tumor weights are shown. The data are showed as the mean ± SD, *P < 0.05 **P < 0.01, ***P < 0.001, ****P < 0.0001. Data were analyzed by (B, H) two-way ANOVA and (C–F, I) Students t test.

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