Table 1 The effect of aberrant protein degradation mediated by E3 ubiquitin ligases and DUBs on CRC.
From: Role of protein degradation systems in colorectal cancer
Ubiquitin enzymes | Gene name | Target protein | Relative signal pathway | Promote/Inhibit | Impact on CRC | PMID |
|---|---|---|---|---|---|---|
E2 | UBE2T | P53 | P53 | Promote cancer | Promote the proliferation, migration, and invasion of CRC cells | 32736946 |
UBE2J1 | RPS3 | NFKB | Inhibit cancer | Inhibit the proliferation, migration, and invasion of CRC cells | 36567344 | |
E3 | FBXL6 | P53 | P53 | Promote cancer | Promote the proliferation of CRC cells | 33568778 |
FBXO22 | PTEN | PTEN | Promote cancer | Promote the proliferation of CRC cells | 32249768 | |
RNF6 | TLE3 | WNT | Promote cancer | Promote the proliferation of CRC cells | 29374067 | |
FBXL20 | E-cadherin | EMT | Promote cancer | Promote migration, and invasion of CRC cells | 24932313 | |
HERC3 | EIF5A2 | Inhibit cancer | Inhibit the migration and invasion of CRC cells | 35064108 | ||
TRIM65 | ARHGAP35 | Promote cancer | Promote migration and invasion of CRC cells | 31332286 | ||
HERC3 | RPL23A | c-Myc | Inhibit cancer | Inhibit the proliferation of CRC cells | 35637966 | |
SMURF2 | ChREBP | Metabolism | Inhibit cancer | Inhibit the proliferation of CRC cells | 31409643 | |
CUL3 | MAT IIα | Inhibit cancer | Inhibit the proliferation of CRC cells | 27213918 | ||
SMURF2 | SIRT1 | Epigenetics | Inhibit cancer | Inhibit the proliferation of CRC cells | 32361710 | |
RBBP6 | IκBα | NFKB | Promote cancer | Promote migration, and invasion of CRC cells | 31685801 | |
MAGI3 | c-Myc | Inhibit cancer | Inhibit CRC cell growth, promote of CRC cell apoptosis, and chemical sensitivity to fluoropyrimidine chemotherapy. | 35864508 | ||
CHIP | P65 | Inhibit cancer | Promote tumor growth and decrease tumor cell migration and invasion. | 24302614 | ||
FBX8 | GSTP1 | Inhibit cancer | Inhibit the proliferation, migration, and invasion of CRC cells | 31024008 | ||
RNF2 | IRF4 | Interferon | Promote cancer | Promote the proliferation, migration, and invasion of CRC cells | 34670117 | |
TRIM21 | MICALL2 | Inhibit cancer | Inhibit migration, and invasion of CRC cells | 36307841 | ||
DUB | PSMD14 | ALK2 | BMP6 | Promote cancer | Promote the proliferation of CRC cells | 31685442 |
USP28 | c-myc | Promote cancer | Promote the proliferation of CRC cells | 24960159 | ||
OTUB1 | β-catenin | WNT | Promote cancer | Promote the proliferation ability and chemical resistance of CRC cells | 35354355 | |
USP44 | Axin1 | Inhibit cancer | Inhibit the proliferation of CRC cells and promoting their apoptosis | 32285989 | ||
USP4 | β-catenin | Promote cancer | Promote the migration, and invasion of CRC cells | 26189775 | ||
UCHL1 | β-catenin | Promote cancer | Promote the proliferation of CRC cells | 22641175 | ||
OTUB2 | PKM2 | Metabolism | Promote cancer | Promote the proliferation of CRC cells | 34671086 | |
USP20 | SOX4 | EMT | Promote cancer | Promote the transfer of CRC | 35405623 | |
USP11 | PPP1CA | ERK-MAPK | Inhibit cancer | Promoted the growth and transfer of CRC | 31521612 |
