Fig. 6: Effect of the apoptosis inhibitors on ARK5-WT and ARK5-KO cell proliferation.

A Effect of etoposide and B Z-VAD-FMK on KMS-11, KMS-11-ARK5-KO#1, Sachi, and Sachi–ARK5-KO#1 cell proliferation. Cells (1 × 103 cells/well) were subjected to treatment with the mentioned concentration of inhibitors for 48 h. Cell growth was estimated by performing MTT assay. Blue and red lines indicate KMS-11, Sachi and KMS-11-ARK5-KO#1, Sachi–ARK5-KO#1 cells, respectively. Data are shown as mean ± SE (n = 3). Asterisks (*) reflect statistically significant differences (*P < 0.05).