Table 1 Drug efficacy and potency in 10 breast cell lines interpreted by IC50, AUC, GR50, and GRmax values.
From: Repurposing proteasome inhibitors for improved treatment of triple-negative breast cancer
Drug | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bortezomib | Carboplatin | Carfilzomib | Celastrol | Cisplatin | Delanzomib | Docetaxel | Doxorubicin | Epirubicin | Epoxomicin | MG 132 | MLN 2238 | MLN 9708 | Nedaplatin | Oprozomib | Paclitaxel | PI-1840 | VR-23 | |
IC50 (µM) | ||||||||||||||||||
BT-549 | NA | NA | 4.4 | 1.3 | 0.053 | NA | NA | 7.6 | 4.6 | NA | 4.3 | NA | NA | 0.15 | NA | NA | NA | NA |
CAL-148 | NA | 0.93 | NA | 3.7 | 0.048 | NA | NA | 0.22 | 0.20 | NA | NA | NA | NA | 0.32 | NA | NA | NA | NA |
HCC1806 | 0.79 | NA | 1.7 | 2.1 | 0.048 | NA | NA | NA | NA | 0.47 | 3.1 | 3 | NA | 0.15 | 6 | NA | NA | NA |
HCC38 | 0.024 | 0.89 | 0.57 | 1.4 | 0.030 | 0.012 | NA | 2.9 | 2.3 | 0.054 | 0.57 | 0.11 | 0.13 | 0.093 | 0.68 | 7.1 | NA | NA |
HCC70 | 0.81 | 0.45 | 2.1 | 1.8 | 0.022 | 3.3 | NA | 3.3 | 1.6 | 0.98 | 3.7 | 2.7 | 4.8 | 0.046 | 7.6 | NA | NA | NA |
MDA-MB-436 | NA | NA | NA | 3.2 | 0.064 | NA | NA | 9.7 | NA | NA | NA | NA | NA | 0.23 | NA | NA | NA | NA |
MDA-MB-453 | NA | NA | NA | 3.7 | 0.24 | NA | NA | 8.1 | 5.3 | NA | NA | 4.3 | NA | NA | NA | NA | NA | NA |
MDA-MB-468 | 0.054 | 0.47 | 0.46 | 1.0 | 0.015 | 0.077 | NA | 3.0 | 2.2 | 0.11 | 1.4 | 0.24 | 0.80 | 0.067 | 3.2 | NA | NA | NA |
MCF-10A | 0.046 | 0.73 | 0.54 | 1.6 | 0.027 | 0.018 | 0.050 | 0.99 | 0.69 | 0.088 | 0.94 | 0.41 | 0.38 | 0.075 | 2.0 | 0.86 | NA | NA |
MCF-7 | NA | NA | NA | 2.8 | 0.16 | NA | NA | 1.8 | 1.5 | 1.2 | NA | NA | NA | NA | NA | NA | NA | 6.0 |
AUC | ||||||||||||||||||
BT-549 | 0.66 | 0.85 | 0.67 | 0.82 | 0.57 | 0.73 | 0.79 | 0.89 | 0.88 | 0.73 | 0.83 | 0.75 | 0.80 | 0.66 | 0.81 | 0.87 | 0.99 | 0.98 |
CAL-148 | 0.77 | 0.92 | 0.84 | 0.85 | 0.48 | 0.77 | 0.89 | 0.72 | 0.73 | 0.78 | 0.89 | 0.83 | 0.88 | 0.78 | 0.90 | 0.92 | 1.0 | 1.0 |
HCC1806 | 0.70 | 0.90 | 0.73 | 0.81 | 0.48 | 0.74 | 0.64 | 0.87 | 0.86 | 0.73 | 0.82 | 0.75 | 0.79 | 0.66 | 0.85 | 0.72 | 1.0 | 1.0 |
HCC38 | 0.40 | 0.88 | 0.71 | 0.79 | 0.45 | 0.42 | 0.78 | 0.83 | 0.81 | 0.47 | 0.71 | 0.59 | 0.59 | 0.62 | 0.73 | 0.81 | 1.0 | 1.0 |
HCC70 | 0.68 | 0.83 | 0.76 | 0.82 | 0.37 | 0.75 | 0.83 | 0.88 | 0.83 | 0.72 | 0.87 | 0.78 | 0.82 | 0.50 | 0.89 | 0.86 | 1.0 | 0.98 |
MDA-MB-436 | 0.75 | 0.91 | 0.73 | 0.85 | 0.62 | 0.79 | 0.69 | 0.85 | 0.84 | 0.77 | 0.86 | 0.88 | 0.86 | 0.76 | 0.84 | 0.78 | 1.0 | 1.0 |
MDA-MB-453 | 0.75 | 0.98 | 0.77 | 0.87 | 0.75 | 0.76 | 0.87 | 0.88 | 0.90 | 0.70 | 0.87 | 0.81 | 0.88 | 0.86 | 0.84 | 0.93 | 1.0 | 0.99 |
MDA-MB-468 | 0.57 | 0.81 | 0.65 | 0.75 | 0.37 | 0.58 | 0.77 | 0.84 | 0.80 | 0.65 | 0.81 | 0.67 | 0.72 | 0.61 | 0.76 | 0.81 | 0.98 | 0.97 |
MCF-10A | 0.59 | 0.90 | 0.66 | 0.81 | 0.42 | 0.62 | 0.63 | 0.72 | 0.69 | 0.58 | 0.78 | 0.72 | 0.72 | 0.57 | 0.79 | 0.73 | 1.0 | 1.0 |
MCF-7 | 0.78 | 0.91 | 0.81 | 0.89 | 0.66 | 0.77 | 0.75 | 0.93 | 0.89 | 0.74 | 0.87 | 0.87 | 0.87 | 0.82 | 0.88 | 0.79 | 1.0 | 0.98 |
GR50 (µM) | ||||||||||||||||||
BT-549 | 0.10 | 0.67 | 1.0 | 1.5 | 0.035 | NA | NA | 5.6 | 4.3 | 0.13 | 1.4 | 0.14 | 0.84 | 0.081 | 0.94 | NA | NA | NA |
CAL-148 | 0.12 | 0.49 | 0.37 | 3.1 | 0.032 | 0.023 | NA | 0.12 | 0.11 | 0.77 | 3.4 | 0.27 | 0.50 | 0.21 | 1.1 | 1.1 | NA | NA |
HCC1806 | 0.38 | NA | 0.95 | 3.4 | 0.042 | NA | NA | 6.0 | 6.2 | 0.29 | 2.5 | 3.3 | 4.3 | 0.12 | 6.0 | 0.84 | NA | NA |
HCC38 | 0.010 | 0.43 | 0.38 | 1.2 | 0.019 | 0.0082 | 0.013 | 0.77 | 0.69 | 0.044 | 0.37 | 0.071 | 0.069 | 0.054 | 0.33 | 0.11 | NA | NA |
HCC70 | 0.10 | 0.27 | 0.48 | 1.2 | 0.015 | 0.37 | NA | 1.8 | 1.0 | 0.14 | 2.1 | 0.74 | 1.2 | 0.30 | 3.7 | 0.38 | NA | NA |
MDA-MB-436 | 0.021 | 0.87 | 0.0018 | 2.4 | 0.043 | 0.029 | 0.0050 | 3.4 | 3.6 | 0.32 | 0.29 | 0.16 | 0.11 | 0.13 | 0.075 | 0.055 | NA | NA |
MDA-MB-453 | 0.063 | NA | 0.22 | 3.4 | 0.095 | 0.027 | NA | 4.6 | 3.2 | 0.015 | 1.7 | 0.64 | 1.8 | 0.41 | 3.5 | NA | NA | 9319.49 |
MDA-MB-468 | 0.017 | 0.24 | 0.11 | 0.75 | 0.0075 | 0.011 | NA | 1.5 | 0.96 | 0.051 | 0.61 | 0.055 | 0.10 | 40.46 | 0.39 | 1.4 | NA | NA |
MCF-10A | 0.012 | 0.76 | 0.11 | 1.8 | 0.028 | 0.012 | 0.0090 | 0.98 | 0.69 | 0.095 | 0.40 | 0.076 | 0.070 | 0.074 | 0.36 | 0.098 | NA | NA |
MCF-7 | 0.031 | 0.36 | 0.19 | 3.3 | 0.015 | 0.037 | 0.0065 | 5.7 | 1.1 | 0.075 | 0.57 | 0.34 | 0.27 | 0.075 | 0.27 | 0.041 | NA | 6334.47 |
GRmax | ||||||||||||||||||
BT-549 | 0.39 | 0.39 | 0.37 | −0.51 | −0.16 | 0.48 | 0.61 | 0.36 | 0.34 | 0.38 | 0.26 | 0.40 | 0.43 | −0.02 | 0.38 | 0.58 | 1.0 | 0.85 |
CAL-148 | 0.17 | 0.03 | −0.01 | −0.84 | −0.97 | 0.39 | 0.74 | 0.15 | 0.14 | 0.11 | 0.22 | 0.18 | 0.40 | −0.93 | 0.14 | 0.51 | 1.0 | 0.95 |
HCC1806 | 0.33 | 0.53 | 0.31 | −0.82 | −0.72 | 0.50 | 0.56 | 0.54 | 0.45 | 0.34 | 0.31 | 0.39 | 0.47 | −0.38 | 0.42 | 0.51 | 0.98 | 0.93 |
HCC38 | −0.99 | 0.03 | −0.99 | −0.96 | −0.67 | −0.97 | 0.17 | 0.01 | −0.03 | −0.74 | −0.98 | −0.99 | −0.99 | −0.58 | −0.98 | −0.50 | 1.0 | 0.95 |
HCC70 | −0.55 | −0.42 | −0.57 | −0.98 | −0.89 | −0.36 | 0.72 | −0.35 | −0.49 | −0.52 | −0.40 | −0.36 | −0.34 | −0.83 | −0.10 | 0.46 | 1.0 | 0.82 |
MDA-MB-436 | −0.76 | 0.41 | −0.89 | −0.63 | 0.17 | −0.84 | −0.81 | 0.26 | 0.26 | 0.37 | −0.88 | −0.78 | −0.82 | 0.22 | −0.93 | −0.97 | 1.0 | 1.0 |
MDA-MB-453 | 0.40 | 0.79 | 0.41 | −0.83 | 0.25 | 0.31 | 0.74 | 0.21 | 0.20 | 0.32 | 0.43 | 0.32 | 0.39 | 0.34 | 0.43 | 0.71 | 0.93 | 0.40 |
MDA-MB-468 | 0 | 0.02 | 0.05 | −0.61 | −0.46 | 0.09 | 0.64 | 0.06 | −0.02 | 0.01 | 0.07 | 0.01 | 0.07 | −0.38 | 0.12 | 0.32 | 0.96 | 0.74 |
MCF-10A | −0.41 | 0.19 | −0.36 | −0.65 | −0.32 | −0.10 | 0.16 | 0.02 | 0.01 | −0.05 | −0.36 | −0.21 | −0.26 | −0.40 | −0.06 | −0.19 | 1.0 | 1.0 |
MCF-7 | −0.43 | −0.15 | −0.45 | −0.30 | −0.96 | −0.28 | −0.44 | 0.44 | 0.42 | 0.42 | −0.32 | −0.29 | −0.48 | −0.57 | −0.45 | −0.56 | 0.97 | 0.82 |
