Fig. 5: Inhibition of TLR2 reduces the p-α-syn-mediated inflammatory response in RSC96 cells. | Cell Death Discovery

Fig. 5: Inhibition of TLR2 reduces the p-α-syn-mediated inflammatory response in RSC96 cells.

From: Phosphorylated α-synuclein deposited in Schwann cells interacting with TLR2 mediates cell damage and induces Parkinson’s disease autonomic dysfunction

Fig. 5: Inhibition of TLR2 reduces the p-α-syn-mediated inflammatory response in RSC96 cells.The alternative text for this image may have been generated using AI.

A Representative western blot bands of TLR2, MyD88, p-NF-κB/NF-κB, and NLRP3 of the RSC96 cells in the PBS, α-syn PFF, CU-CPT22, and α-syn PFF + CU-CPT22 groups. n = 4. B–E The quantitative analysis of TLR2, MyD88, p-NF-κB/NF-κB, and NLRP3. n = 4. F, G The levels of TNF-α and IL-1β were detected by ELISA. n = 10. H Cell viability at 24 h, 36 h, and 48 h after α-syn PFF and CU-CPT22 stimulation was detected by CCK8 assay. n = 6. Data were presented as mean ± SEM and analyzed by two-way ANOVA followed by Bonferroni’s multiple comparison test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns, not significant. Cell experiments were repeated three times independently.

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