Fig. 3: Molecular mechanisms by which H19 acts as ceRNA to regulate PCD. | Cell Death Discovery

Fig. 3: Molecular mechanisms by which H19 acts as ceRNA to regulate PCD.

From: Long noncoding RNA H19: functions and mechanisms in regulating programmed cell death in cancer

Fig. 3

H19 regulates apoptosis, autophagy, ferroptosis, and necroptosis in tumor cells as a ceRNA. H19 and mRNA competitively bind with the same microRNA response elements (MRE), and H19 expression directly affects the number of miRNAs that can be bound by the corresponding mRNA. That is, H19 indirectly regulates mRNA expression through the bridge of MRE, thus regulating PCD.

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