Fig. 3: Involvement of human SOX TFs in cancer.
The participation of SOX TFs in various cancers has been disclosed, including brain tumor [103, 105, 107, 113, 118, 125, 127, 131, 154, 155, 176, 177, 183, 184, 188, 194], thyroid cancer [98], lung cancer [41, 65, 73, 104, 135, 136, 151, 164, 193], breast cancer [121, 145, 146, 153, 158, 171, 181], hematologic cancer [123, 178], liver cancer [82, 84, 87, 89, 93, 95, 108, 111, 115, 132, 152], gastric cancer [91, 92, 112, 137, 138, 160, 190], colorectal cancer [58, 69, 70, 77, 85, 96, 110, 124, 149, 189], ovarian cancer [100, 120, 169, 173], bladder cancer [201], prostate cancer [64, 81, 90, 116, 117, 130, 163], testicular cancer [110, 195] and cervical cancer [114, 134]. The red fonts stand for upregulation, blue indicates downregulation and black for either upregulation or downregulation.
