Fig. 8: Hsa_circ_0021205/miR-195-5p/HSL axis promoted abnormal lipolysis in vitro and accelerates glioblastoma proliferation in vivo. | Cell Death Discovery

Fig. 8: Hsa_circ_0021205/miR-195-5p/HSL axis promoted abnormal lipolysis in vitro and accelerates glioblastoma proliferation in vivo.

From: Hsa_circ_0021205 enhances lipolysis via regulating miR-195-5p/HSL axis and drives malignant progression of glioblastoma

Fig. 8

A Relative intracellular FAs levels in SNB19 and LN229 cells after transfection. B, C Relative intracellular DAG and MAG levels in SNB19 and LN229 cells detected by ELISA after transfection. D Oil red O staining was conducted to stain intracellular neutral fat of SNB19 and LN229 cells in vitro. E, F In vivo evaluation of glioblastoma growth in subcutaneous tumor model. SNB19 cells with sh-NC, sh-hsa_circ_0021205, sh-hsa_circ_0021205 + HSL-EV, or sh-hsa_circ_0021205 + HSL-OE, respectively, were inoculated in the right subcutaneous axillary region of BALB/c nude mice. G, H Ki-67 positive cells were counted in the sections of xenografts by immunohistochemical staining. I Representative intracranial tumor xenografts of HE staining images are shown. Data are expressed as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

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