Table 1 Autophagy receptors participate in macromitophagy in severe infections.
From: Mechanism and role of mitophagy in the development of severe infection
Name | Subcellular location | Molecular interaction | Special pathophysiological effects |
|---|---|---|---|
Bcl2 interacting protein 3 like (NIX/BNIP3L) [35, 76, 187,188,189] | OMM | Binding ATG8; Recruiting Parkin to mitochondria | Participating in reticulocyte maturation and macrophage activation; Protecting I/R injury ischemia–reperfusion in the cerebrum; SARS-CoV-2 ORF10 induces macromitophagy by combining with NIX; Promoting HHV-8 replication |
OMM | Binding ATG8; Inhibiting degradation of PINK1; Recruiting DRP1 | Coordinating the process of apoptosis and macromitophagy against cell stress; Alleviating sepsis kidney injury; Promoting generation and survival of memory immunocytes | |
OMM | Binding ATG8; Recruiting DRP1 and ULK1 | Belonging to BH3-only proteins to coordinate the role of apoptosis and macromitophagy against cell stress | |
OMM | Binding ATG8; Binding BAX/BAK | Inhibiting BAX/BAK induced apoptosis; Promoting Ub-independent mitophagy | |
FUN14 domain-containing protein 1 (FUNDC1) [32, 197,198,199,200] | OMM/MAM | Dephosphorylated FUNDC1 binds ATG8; Recruiting ULK1 and DRP1 | Inhibiting IL-1β secretion in macrophage and alleviating septic lung injury and cardiomyopathy; Regulating mitochondrial dynamics |
Activating molecule in Beclin1-regulated autophagy 1 (AMBRA1) [201,202,203] | From cytoplasm to OMM | Binding ATG8 or ATAD3A; Activating PIK3C3 complex 1 by binding BECN1 | Compensating for the deficient PINK1/Parkin-dependent mitophagy in Parkinson disease; Protecting neurons from hypoxia; Blocking PINK1 import into mitochondria |
IMM | Binding ATG8; Stabilizing PINK1 on the OMM | Alleviating septic kidney injury; Facilitating macrophage to scavenge P. aeruginosa and mROS | |
Cardiolipin [110] | From IMM to OMM | Binding ATG8 | Promoting mitochondrial apoptosis or macromitophagy in the severe infection |
