Fig. 6: PATJ depletion induces a pro-inflammatory phenotype characterized by increased expression of cell adhesion molecules and production of IL-6 and IL-8. | Cell Death Discovery

Fig. 6: PATJ depletion induces a pro-inflammatory phenotype characterized by increased expression of cell adhesion molecules and production of IL-6 and IL-8.

From: Role of PATJ in stroke prognosis by modulating endothelial to mesenchymal transition through the Hippo/Notch/PI3K axis

Fig. 6: PATJ depletion induces a pro-inflammatory phenotype characterized by increased expression of cell adhesion molecules and production of IL-6 and IL-8.The alternative text for this image may have been generated using AI.

A Differential expression of the cell adhesion molecules ICAM-1 and CD44, as well as TRAF6 in PATJ KD cells, revealed by WB analysis. B, C Basal secretion of IL-6 (B) and IL-8 (C). PATJ KD3 cells produce significantly higher amounts of IL6. D, E Secretion of IL-6 (D) and IL-8 (E) after LPS incubation. Bars represent the mean of media cytokine detection (pg/ml) ± SD of three independent experiments. Counts were performed after 24 h of cell culture (B, C) or after 2, 4, or 8 h incubation with LPS (D, E). *p < 0.05, as compared to CTL cells (ANOVA followed by Bonferroni’s test).

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