Fig. 1: FOXC1 is highly expressed in esophageal squamous cell carcinoma and negatively correlates with survival probability. | Cell Death Discovery

Fig. 1: FOXC1 is highly expressed in esophageal squamous cell carcinoma and negatively correlates with survival probability.

From: IGF-1-mediated FOXC1 overexpression induces stem-like properties through upregulating CBX7 and IGF-1R in esophageal squamous cell carcinoma

Fig. 1

A, B Heatmap of differentially expressed genes of GSE26886 (A) and GSE53625 (B). C A Venn diagram illustrates the overlap of upregulated genes in both GSE26886 and GSE53625(fold change >3.0).FOXC1 is upregulated in both GSE26886 and GSE53625. D TCGA database shows that FOXC1 is highly expressed in ESCC tissues compared to normal esophageal tissues. E Esophageal squamous cell carcinoma tissue microarray from 79 patients shows that FOXC1 is highly expressed in ESCC tissues compared to normal esophageal tissues. F The expression level of FOXC1 in ESCC was negatively correlated with patient survival rate. G, H The expression level of FOXC1 is corresponding to ESCC progression. I FOXC1 expression level in ESCC was higher than that in corresponding paraneoplastic tissues of 5 randomly selected patients. J FOXC1 is higher in ESCC cell lines especially in KYSE-150, ECA-109, TE-1, and KYSE-30 than in normal esophageal epithelial cell line HET-1A. *P < 0.05; **P < 0.01; ***P < 0.001;****p < 0.0001.

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