Fig. 3: Effects of glucose metabolic reprogramming on CRC.
From: The effects of metabolism on the immune microenvironment in colorectal cancer
1) The rise in three proxies marked the upregulation of glycolysis in CRC and hyperglycaemia in CRC, both of which resulted in worsening colorectal cancer by affecting T cells through the rising G6PD, MondoA-TXNIP signalling pathway, and Akt/mTORC1-CRC cellular autophagy pathway, respectively. 2) Lactate metabolism is upregulated in CRC, and upregulation of LDHA downregulates CD8 + T cells through downregulation of TH1-INFγ, and also enables polarization of TAMs to M2 TAMs through G protein-coupled receptor-dependent expression of ICER. G6PD glucose-6-phosphate dehydrogenase; LDHA lactate dehydrogenase A Gene; ICER inducible cAMP early repressor.
