Fig. 8: Generation of memory B cells upon viral infection.
From: B cell memory: from generation to reactivation: a multipronged defense wall against pathogens
a Diagram illustration of the MBCs’ generation upon viral (influenza) infection. Displayed in purple are the antibodies against immunodominant viral epitopes of the influenza virus (anti-HA head domain), while the green antibodies are against the immunologically subdominant conserved viral epitopes (anti-HA stalk domain). b Broadly reactive low affinity GC B cells are more likely to join the MBC pool. Autoreactive germinal center B cells are thought to have a lower affinity for both self-antigens and foreign antigens and express less CD86, resulting in reduced Tfh cell assistance and joining the memory B cells pool. Reproduced with permission.
