Fig. 2: Upregulation of AKR1C1 promotes gefitinib resistance in LUAD cells. | Cell Death Discovery

Fig. 2: Upregulation of AKR1C1 promotes gefitinib resistance in LUAD cells.

From: NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence

Fig. 2

A Overlapping protein-coding genes of GEO datasets GSE199627 and GSE169513. B Heatmap showing the overlapping ferroptosis-related genes in GSE199627 and GSE169513 dataset. C The expression of AKR1C1 in EGFR-mutated LUAD cells and matched gefitinib-resistant strains, assayed by western blotting. D Effects of sh-AKR1C1 on the expression of AKR1C1 in gefitinib-resistant strains of EGFR-mutated LUAD cells. E Effects of AKR1C1-overexpression on the expression of AKR1C1 in gefitinib-sensitive EGFR-mutated LUAD cells. F Effects of sh-AKR1C1 on the sensitivity to gefitinib of PC9/GR and HCC827/GR cells, and effects of AKR1C1-overexpression on the sensitivity to gefitinib of PC9 and HCC827 cells. ***P < 0.001.

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