Fig. 3: AKR1C1 contributed to ferroptosis protection in LUAD cells in vitro. | Cell Death Discovery

Fig. 3: AKR1C1 contributed to ferroptosis protection in LUAD cells in vitro.

From: NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence

Fig. 3

A–D Effects of sh-AKR1C1 on JC-1 monomer/aggregate ratio, oxidized C11-BODIPY, MDA production, and mitochondria in HCC827/GR cells. E–H Effects of AKR1C1 overexpression on JC-1 monomer/aggregate ratio, oxidized C11-BODIPY, MDA production, and mitochondria in HCC827 cells. Scale bars for C11-BODIPY staining, 20 μm. Scale bars for TEM, 0.2 μm. ***P < 0.001.

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