Fig. 6: NEAT1_1 induces ferroptosis protection and gefitinib resistance in LUAD in vitro. | Cell Death Discovery

Fig. 6: NEAT1_1 induces ferroptosis protection and gefitinib resistance in LUAD in vitro.

From: NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence

Fig. 6

A Effects of sh-NEAT1_1 on the sensitivity to gefitinib of PC9/GR cells. B Effects of NEAT1_1-overexpression on the sensitivity to gefitinib of PC9 cells. C Effects of NEAT1_1 on MDA production in PC9/GR and PC9 cells. D, E Representative fluorescence of JC-1 monomer and aggregate in PC9/GR and PC9 cells. Scale bars, 20 μm. F Effect of NEAT1_1 on the JC-1 monomer/aggregate ratio in PC9/GR and PC9 cells. G, H Representative fluorescence of C11-BODIPY in PC9/GR and PC9 cells. Scale bars, 20 μm. I Effect of NEAT1_1 on oxidized C11-BODIPY in PC9/GR and PC9 cells. J Representative TEM image of PC9/GR and PC9 cells treated with DSMO or gefitinib. Scale bars, 0.2 μm. ***P < 0.001.

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