Fig. 8: The NEAT1_1/miR-338-3p/AKR1C1 axis contributes to gefitinib resistance of LUAD in vivo. | Cell Death Discovery

Fig. 8: The NEAT1_1/miR-338-3p/AKR1C1 axis contributes to gefitinib resistance of LUAD in vivo.

From: NEAT1_1 confers gefitinib resistance in lung adenocarcinoma through promoting AKR1C1-mediated ferroptosis defence

Fig. 8

A PC9/GR cell-derived xenograft tumors of sacrificed mice with gefitinib or PBS treatment at the end of the experiment and their growth curves. B PC9 cell-derived xenograft tumors of sacrificed mice with gefitinib or PBS treatment at the end of the experiment and their growth curves. C Representative IHC images of AKR1C1 (brown) in xenograft tumor tissues derived from PC9/GR or PC9 cells. Scale bars, 50 μm. D IHC staining scores of AKR1C1 in xenograft tumor tissues derived from PC9/GR or PC9 cells. E, F Representative IF images of MDA (red) in xenograft tumor tissues derived from PC9/GR or PC9 cells. G Schematic illustration depicting a proposed model of the molecular mechanism of NEAT1_1/miR-338-3p/AKR1C1 axis in initiating gefitinib resistance in LUAD. *P < 0.05; **P < 0.01; ***P < 0.001.

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