Fig. 9: Proposed model of NEAT1_1 conferring gefitinib resistance in LUAD by upregulating AKR1C1.

NEAT1_1 sponges miR-338a-3p and upregulates AKR1C1 in LUAD cells harboring classical EGFR mutation. NEAT1_1/miR-338a-3p/AKR1C1 axis drives a ferroptosis protection and thereby promotes gefitinib resistance and malignant behaviors.