Fig. 4: Micronuclei formation upon wars-1 KD. | Cell Death Discovery

Fig. 4: Micronuclei formation upon wars-1 KD.

From: Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans

Fig. 4

Knocking down wars-1 results in the formation of micronuclei and fragmented chromatin, indicating a massive genotoxic insult. The second row is the zoom-in of the dashed boxes in the top row. Micronuclei formed upon wars-1 KD are of various sizes, ranging from 0.74 to 1.49 μm in diameter (Shown under the wars-1 panel). Arrowheads point to the micronuclei, while the arrow indicates fragmented and frayed-looking chromosomes. The scale bar in the top row represents 10 μm, and the bar in the second row is equal to 5 μm.

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