Fig. 3: The primary types and mechanisms of RNA methylation.
From: Methylation in cornea and corneal diseases: a systematic review
A The methylation modifications occurring at different sites of mRNA reflect the diversity of RNA methylation. B The most representative RNA methylations are m6A. C m6A is catalyzed by the “writers” (METTL3/METTL14/WTAP) and removed by FTO and ALKBH5 “erasers”. In addition, YTHDC1, YTHDC2 and YTHDF1/2/3 serve as m6A methylation-dependent binding proteins, acting as “reader” to regulate RNA stability, splicing, degradation, and translation functionalities. (Figure was created with BioRender.com).
