Fig. 5: The methylation balance is disrupted in corneal diseases.
From: Methylation in cornea and corneal diseases: a systematic review
Maintaining the equilibrium between methylation and demethylation is therefore necessary for sustaining proper cornea function. In corneal diseases, methylation modifications can trigger changes in corneal function and related pathological processes. Regulatory factors for methylation modification can cause changes in methylation levels which, in turn, can affect gene expression. Ultimately, these changes can lead to neovascularization, activation of ROS, and increased expression of inflammatory-related factors. (Figure was created with BioRender.com).
