Fig. 8: Inhibitory effect of SR-18292 on cell survival and recovery from EtOH induced damage in neuronal PC12 cells. | Cell Death Discovery

Fig. 8: Inhibitory effect of SR-18292 on cell survival and recovery from EtOH induced damage in neuronal PC12 cells.

From: PGC-1a mediated mitochondrial biogenesis promotes recovery and survival of neuronal cells from cellular degeneration

Fig. 8

A–C Quantification of cell viability, the percentage of cells with neurites, and the mean neurite length per cell in neuronal PC12 cells treated alone with different concentration of SR-18292 (50, 75, 100 µM) for 4 and 20 h. Data are presented as mean ± SEM. *P < 0.05, vs. control group. D–F Quantification of cell viability, the percentage of cells with neurites, and the mean neurite length per cell in neuronal PC12 cells with corresponding treatment. Data are presented as mean ± SEM. ****P < 0.0001, vs. control group; ##P < 0.01, ####P < 0.0001, vs. EtOH 3 h group; ^^^^P < 0.0001, vs. Washed 4 h group; !!!!P < 0.0001, vs. Washed 20 h group. G, H Quantification of the percentage of cells with fragmented mitochondria and the TMRM mean fluorescence intensity in neuronal PC12 cells treated alone with different concentrations of SR-18292 (50, 75, 100 µM) for 4 and 20 h. I, J Quantification of cell viability, the percentage of cells with neurites, and the mean neurite length per cell in neuronal PC12 cells with corresponding treatment. Data are presented as mean ± SEM. ****P < 0.0001, vs. control group; ####P < 0.0001, vs. EtOH 3 h group; ^^^^P < 0.0001, vs. Washed 4 h group; !!!!P < 0.0001, vs. Washed 20 h group.

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