Fig. 3: RNA-sequencing analysis of HUVECs. | Cell Death Discovery

Fig. 3: RNA-sequencing analysis of HUVECs.

From: Replicative senescence and high glucose induce the accrual of self-derived cytosolic nucleic acids in human endothelial cells

Fig. 3: RNA-sequencing analysis of HUVECs.

A Volcano plot depicting the impact of Senescence on the gene expression patterns in normal glucose levels. Some of the DE gene names were omitted due to the overlapping labels. In blue: downregulated DE genes; in red: upregulated DE genes; in green: non-significant (ns) genes. B Results of functional protein network analysis of 48 genes differentially expressed (adj. p-value < 0.10 and logFC > 1.5) in Senescent cells compared to young in normal glucose culture media. In red are highlighted proteins-players involved in interferon Alpha/Beta signaling. Nodes correspond to transcripts and edges represent protein–protein interactions: turquoise—known from curated databases, pink—known from experimentally determined, green—predicted based on gene neighborhood, red—predicted based on gene fusion, blue—predicted based on gene co-occurrence, lime—inferred from text mining, black—revealed from co-expression evidence, light blue—inferred from protein homology. C Volcano plot depicting the impact of Senescence on the gene expression patterns in high glucose levels. Some of the DE gene names were omitted due to the overlapping labels. In blue: downregulated DE genes; in red: upregulated DE genes; in green: non-significant (ns) genes.

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