Table 1 Genes differentially expressed (adj.p-value < 0.10 and logFC > 1.5) in senescent cells compared to young in normal glucose levels.

1

ENSG00000092969

4.7564

3.6305

9.4846

0.0000

0.0118

5.6387

TGFB2

transforming growth factor beta 2 [Source:HGNC Symbol;Acc:HGNC:11768]

Over-expressed

U:5; D:1

2

ENSG00000005187

3.7810

1.5349

7.5726

0.0000

0.0254

3.1866

ACSM3

acyl-CoA synthetase medium chain family member 3 [Source:HGNC Symbol;Acc:HGNC:10522]

NA

U:2; D:0

3

ENSG00000105855

2.2509

3.8918

7.5565

0.0000

0.0254

4.0563

ITGB8

integrin subunit beta 8 [Source:HGNC Symbol;Acc:HGNC:6163]

NA

U:3; D:2

4

ENSG00000079616

−1.5695

5.6850

−7.5080

0.0000

0.0254

4.1239

KIF22

kinesin family member 22 [Source:HGNC Symbol;Acc:HGNC:6391]

Under-expressed

U:0; D:5

5

ENSG00000157601

3.5772

4.3326

7.4619

0.0000

0.0254

3.9681

MX1

MX dynamin like GTPase 1 [Source:HGNC Symbol;Acc:HGNC:7532]

Over-expressed

U:4; D:0

6

ENSG00000144554

−2.0280

4.3566

−7.4045

0.0000

0.0254

3.9519

FANCD2

FA complementation group D2 [Source:HGNC Symbol;Acc:HGNC:3585]

Under-expressed

U:2; D:7

7

ENSG00000185745

4.2406

0.9891

6.5060

0.0000

0.0606

1.9589

IFIT1

interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407]

Over-expressed

U:2; D:1

8

ENSG00000144712

−1.8628

2.8348

−6.4925

0.0000

0.0606

2.7076

CAND2

cullin associated and neddylation dissociated 2 (putative) [Source:HGNC Symbol;Acc:HGNC:30689]

NA

U:1; D:1

9

ENSG00000138675

3.4917

2.7006

6.4308

0.0000

0.0606

2.4552

FGF5

fibroblast growth factor 5 [Source:HGNC Symbol;Acc:HGNC:3683]

NA

U:2; D:1

10

ENSG00000165072

4.8361

2.7871

6.4243

0.0000

0.0606

2.3163

MAMDC2

MAM domain containing 2 [Source:HGNC Symbol;Acc:HGNC:23673]

Over-expressed

U:2; D:0

11

ENSG00000141449

3.5485

2.3757

6.3410

0.0000

0.0623

2.3068

GREB1L

GREB1 like retinoic acid receptor coactivator [Source:HGNC Symbol;Acc:HGNC:31042]

NA

U:0; D:1

12

ENSG00000105426

1.7894

5.8019

6.2349

0.0000

0.0669

2.4319

PTPRS

protein tyrosine phosphatase receptor type S [Source:HGNC Symbol;Acc:HGNC:9681]

NA

U:1; D:1

13

ENSG00000105825

4.9582

6.2532

6.1551

0.0000

0.0696

2.3023

TFPI2

tissue factor pathway inhibitor 2 [Source:HGNC Symbol;Acc:HGNC:11761]

NA

U:3; D:2

14

ENSG00000067048

−5.2633

−0.8843

−6.0557

0.0001

0.0712

0.5763

DDX3Y

DEAD-box helicase 3 Y-linked [Source:HGNC Symbol;Acc:HGNC:2699]

NA

U:1; D:2

15

ENSG00000137193

−2.1836

3.1077

−6.0356

0.0001

0.0712

2.0950

PIM1

Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986]

Under-expressed

U:7; D:2

16

ENSG00000115896

2.0854

3.7362

6.0024

0.0001

0.0712

2.0557

PLCL1

phospholipase C like 1 (inactive) [Source:HGNC Symbol;Acc:HGNC:9063]

NA

U:1; D:1

17

ENSG00000149212

2.3423

3.4360

5.9643

0.0001

0.0712

1.9926

SESN3

sestrin 3 [Source:HGNC Symbol;Acc:HGNC:23060]

NA

U:2; D:0

18

ENSG00000167772

4.2680

4.5042

5.8609

0.0001

0.0743

1.8559

ANGPTL4

angiopoietin like 4 [Source:HGNC Symbol;Acc:HGNC:16039]

Over-expressed

U:7; D:1

19

ENSG00000172738

2.7465

3.2557

5.7940

0.0001

0.0743

1.7296

TMEM217

transmembrane protein 217 [Source:HGNC Symbol;Acc:HGNC:21238]

Over-expressed

U:1; D:0

20

ENSG00000067646

−4.9956

−2.4558

−5.7418

0.0001

0.0743

−0.5138

ZFY

zinc finger protein Y-linked [Source:HGNC Symbol;Acc:HGNC:12870]

NA

NA

21

ENSG00000138623

2.7519

1.4124

5.6953

0.0001

0.0743

1.3690

SEMA7A

semaphorin 7A (John Milton Hagen blood group) [Source:HGNC Symbol;Acc:HGNC:10741]

NA

U:2; D:2

22

ENSG00000066735

−3.0296

2.9913

−5.6590

0.0001

0.0743

1.5641

KIF26A

kinesin family member 26A [Source:HGNC Symbol;Acc:HGNC:20226]

NA

U:1; D:2

23

ENSG00000145242

4.5827

1.3860

5.6230

0.0001

0.0743

0.9377

EPHA5

EPH receptor A5 [Source:HGNC Symbol;Acc:HGNC:3389]

NA

NA

24

ENSG00000026103

1.8381

3.8246

5.6224

0.0001

0.0743

1.5320

FAS

Fas cell surface death receptor [Source:HGNC Symbol;Acc:HGNC:11920]

Over-expressed

U:4; D:1

25

ENSG00000189056

4.9245

3.4932

5.6037

0.0001

0.0743

1.4219

RELN

reelin [Source:HGNC Symbol;Acc:HGNC:9957]

NA

U:0; D:1

26

ENSG00000164484

3.0426

2.0086

5.6013

0.0001

0.0743

1.2714

TMEM200A

transmembrane protein 200A [Source:HGNC Symbol;Acc:HGNC:21075]

NA

U:1; D:0

27

ENSG00000165246

−5.5321

−2.3438

−5.5977

0.0001

0.0743

−0.5528

NLGN4Y

neuroligin 4 Y-linked [Source:HGNC Symbol;Acc:HGNC:15529]

NA

NA

28

ENSG00000119669

−1.7321

6.2914

−5.5917

0.0001

0.0743

1.4829

IRF2BPL

interferon regulatory factor 2 binding protein like [Source:HGNC Symbol;Acc:HGNC:14282]

NA

U:1; D:1

29

ENSG00000163071

1.5607

3.9695

5.5669

0.0001

0.0743

1.4508

SPATA18

spermatogenesis associated 18 [Source:HGNC Symbol;Acc:HGNC:29579]

Over-expressed

U:4; D:0

30

ENSG00000147459

1.5019

5.5256

5.5435

0.0001

0.0743

1.4137

DOCK5

dedicator of cytokinesis 5 [Source:HGNC Symbol;Acc:HGNC:23476]

NA

U:0; D:1

31

ENSG00000066248

5.8635

−0.3949

5.5192

0.0001

0.0743

−0.2762

NGEF

neuronal guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:7807]

NA

U:1; D:2

32

ENSG00000178726

2.0545

6.0271

5.5139

0.0001

0.0743

1.3684

THBD

thrombomodulin [Source:HGNC Symbol;Acc:HGNC:11784]

NA

U:5; D:2

33

ENSG00000163808

−1.9526

3.6393

−5.4162

0.0002

0.0800

1.2267

KIF15

kinesin family member 15 [Source:HGNC Symbol;Acc:HGNC:17273]

Under-expressed

U:0; D:5

34

ENSG00000170430

−2.9235

1.2568

−5.4140

0.0002

0.0800

0.9960

MGMT

O-6-methylguanine-DNA methyltransferase [Source:HGNC Symbol;Acc:HGNC:7059]

Under-expressed

NA

35

ENSG00000135074

1.5278

6.1145

5.4140

0.0002

0.0800

1.2119

ADAM19

ADAM metallopeptidase domain 19 [Source:HGNC Symbol;Acc:HGNC:197]

Over-expressed

U:2; D:0

36

ENSG00000089127

2.4090

3.2450

5.3647

0.0002

0.0821

1.1398

OAS1

2’-5’-oligoadenylate synthetase 1 [Source:HGNC Symbol;Acc:HGNC:8086]

NA

U:3; D:0

37

ENSG00000101311

2.0626

3.1539

5.3319

0.0002

0.0844

1.0810

FERMT1

FERM domain containing kindlin 1 [Source:HGNC Symbol;Acc:HGNC:15889]

NA

U:1; D:0

38

ENSG00000126709

3.8129

4.6387

5.2545

0.0002

0.0933

0.9805

IFI6

interferon alpha inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054]

Over-expressed

U:4; D:1

39

ENSG00000184545

2.2951

3.4372

5.2215

0.0002

0.0961

0.9246

DUSP8

dual specificity phosphatase 8 [Source:HGNC Symbol;Acc:HGNC:3074]

NA

U:1; D:0

40

ENSG00000119514

2.4543

2.6776

5.1574

0.0002

0.0969

0.8039

GALNT12

polypeptide N-acetylgalactosaminyltransferase 12 [Source:HGNC Symbol;Acc:HGNC:19877]

NA

U:3; D:1

41

ENSG00000171346

2.1039

3.0590

5.1547

0.0002

0.0969

0.8167

KRT15

keratin 15 [Source:HGNC Symbol;Acc:HGNC:6421]

NA

U:1; D:0

42

ENSG00000185507

1.7958

3.9681

5.1542

0.0002

0.0969

0.8260

IRF7

interferon regulatory factor 7 [Source:HGNC Symbol;Acc:HGNC:6122]

NA

U:5; D:1

43

ENSG00000113368

−1.5113

6.3069

−5.1485

0.0002

0.0969

0.7895

LMNB1

lamin B1 [Source:HGNC Symbol;Acc:HGNC:6637]

Under-expressed

U:4; D:33

44

ENSG00000156113

3.7668

3.6239

5.1414

0.0002

0.0969

0.7966

KCNMA1

potassium calcium-activated channel subfamily M alpha 1 [Source:HGNC Symbol;Acc:HGNC:6284]

NA

U:1; D:1

45

ENSG00000154262

2.7302

3.8470

5.1331

0.0002

0.0969

0.7939

ABCA6

ATP binding cassette subfamily A member 6 [Source:HGNC Symbol;Acc:HGNC:36]

NA

U:1; D:1

46

ENSG00000186918

−2.3673

2.3481

−5.1207

0.0003

0.0969

0.7447

ZNF395

zinc finger protein 395 [Source:HGNC Symbol;Acc:HGNC:18737]

NA

U:1; D:3

47

ENSG00000115194

−2.5308

1.5416

−5.1075

0.0003

0.0970

0.6628

SLC30A3

solute carrier family 30 member 3 [Source:HGNC Symbol;Acc:HGNC:11014]

NA

U:0; D:1

48

ENSG00000147697

1.9285

3.1885

5.0923

0.0003

0.0975

0.7268

GSDMC

gasdermin C [Source:HGNC Symbol;Acc:HGNC:7151]

NA

NA