Fig. 2: RIPK3 induces inflammasome activation and cytokine production. | Cell Death Discovery

Fig. 2: RIPK3 induces inflammasome activation and cytokine production.

From: RIPK3 signaling and its role in regulated cell death and diseases

Fig. 2: RIPK3 induces inflammasome activation and cytokine production.

Cells undergoing RIPK3-induced necroptosis release intracellular DAMPs. In dendritic cells (DCs) and macrophages, RIPK3 regulates the production of cytokines/chemokines by regulating the NF-κB pathway. The RIPK3 protein induces the production of IL-1β and IL-18 through the caspase-8–RIPK1–NLRP3 axis. In addition, it induces the production of NF-kB through the TRIF–RIPK3 pathway to stimulate the production of cytokines.

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