Fig. 1: General structure of Tspan proteins.
From: Tspan protein family: focusing on the occurrence, progression, and treatment of cancer
Tspan proteins include four transmembrane structural domains (TM), two short N-terminal and C-terminal cytoplasmic tails, and two extracellular portions called the EC1 and EC2 structural domains. EC2 is the functional region of the Tspan protein family and often contains a conserved CCG sequence.
