Fig. 1: PCK1 overexpression in uveal melanoma correlates with poor overall survival and advanced disease stage.
From: Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma
Expression of PCK1 mRNA and protein in described UVM tissues (“T”) and surrounding normal tissues (“N”) was tested by qRT-PCR and Western blotting assays (A–C, n = 9 tissues per group). Expression of PCK1 mRNA (D) and protein (E and F) in described UVM cells and primary human melanocytes (“melanocytes”) was tested as well (n = 5, biological repeats). TCGA Kaplan-Meier survival analyses demonstrated the association between PCK1 expression and overall survival in UVM patients in TCGA database (G). TCGA cohort demonstrates PCK1 expression in UVM patients with different pathological stages (H). *P < 0.05 vs. “N” tissues or– “melanocytes” (A–F). *P < 0.05 (H).
