Fig. 9: The proposed signaling cascade carton of the study.
From: Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma
The results suggest that PCK1 promotes Gαi3 expression possibly by enhancing the transcriptional activity of GATA4. This, in turn, leads to increased Akt activation, thereby facilitating the growth of UVM cells both in vitro and in vivo. Considering the established role of PCK1 in angiogenesis, which is pivotal for UVM progression, these findings underscore PCK1 significant role in advancing UVM progression.
