Table 1 The functions of circRNAs acting as miRNA sponges in NPC.
From: Emerging roles of circular RNAs in nasopharyngeal carcinoma: functions and implications
CircRNA | Expression | Function | Sponge target/miRNA target | Ref |
|---|---|---|---|---|
circCTDP1 | Up | Proliferation(+) Apoptosis(−) Migration(+) Invasion(+) | miR-320b/HOXA10 | [51] |
circ_0000523 | Up | Proliferation(+) | miR-1184/COL1A1 | [52] |
circHIPK3 | Up | Proliferation(+) Migration(+) Invasion (+) Metastasis(+) | miR-4288/ELF3 | [53] |
circSOX9 | Up | Proliferation(+) Migration(+) Invasion (+) Metastasis(+) | miR-485-3p/SOX9 | [74] |
circZNF609 | Up | Proliferation(+) Migration(+) Invasion(+) | miR-150-5p/Sp1 | [54] |
circZNF609 | Up | Proliferation(+) Migration(+) Invasion(+) Glycolysis(+) | miR-338-3p/HRAS | [78] |
circZNF609 | Up | Proliferation(+) Migration(+) Angiogenesis(+) | miR-145/STMN1 | [79] |
circ_0081534 | Up | Proliferation(+) Invasion (+) | miR-5085p/FN1 | [55] |
circTGFBR2 | Down | Proliferation(-) Apoptosis(+) Migration(-) Invasion(-) | miR-107/TGFBR2 | [60] |
circITCH | Down | Proliferation(-) Migration(-) Invasion(-) Metastasis(-) | miR-214/PTEN | [61] |
circ_0046263 | Up | Proliferation(+) Migration(+) Invasion(+) | miR-133a-5p/IGFBP3 | [57] |
circCRIM1 | Up | Migration(+) Invasion(+) Metastasis(+) | miR-422a/FOXQ1 | [68] |
circCRIM1 | Up | Proliferation(+) Migration(+) Invasion(+) | miR-34c-5p/FOSL1 | [56] |
circTRAF3 | Up | Proliferation(+) Apoptosis(−) Invasion(+) Metastasis(+) | miR-203a-3p/AKT3 | [64] |
circ_0000215 | Up | Proliferation(+) Migration(+) Invasion(+) Metastasis(+) | miR-512-5p/PIK3R1 | [59] |
circSETD3 | Up | Invasion(+) Migration(+) | miR-615-5p and miR-1538/MAPRE1 | [67] |
circMAN1A2 | Up | Proliferation(+) Migration(+) Invasion(+) Metastasis(+) | miR-135a-3p/UBR5 | [73] |
circNOTCH1 | Up | Proliferation(+) Migration(+) Invasion(+) | miR-34c-5p/c-Myc | [58] |
circ_0004788 | Up | Proliferation(+) Apoptosis(−) Migration(+) Invasion(+) Angiogenesis(+) | miR-515-5p/FGF2 | [62] |
circ_0008450 | Up | Proliferation(+) Apoptosis(−) Migration(+) Invasion (+) | miR-577/CXCL9 | [63] |
circFIP1L1 | Up (after radiation) | Proliferation(-) Apoptosis(+) | miR-1253/EIF4A3 | [66] |
circFIP1L1 | Not mentioned | Proliferation(-) Angiogenesis(-) | miR-125a-5p/VEGFA | [80] |
circCDR1as | Up | Proliferation(+) Glycolysis(+) | miR-7-5p/E2F3 | [77] |
circ_0028007 | Up | Proliferation(+) Apoptosis(−) Migration(+) Invasion(+) Angiogenesis(+) | miR-656-3p/ELF2 | [65] |
circPARD3 | Up | Stemness(+) | miR-579-3p/SIRT1 | [82] |
circRPMS1 | Up | Proliferation(+) Apoptosis(−) Invasion (+) | miR203, miR-31 and miR-451 | [85] |
