Fig. 1: The model of Hippo sinaling pathway in mammalian cells and the activity of Hippo sinaling pathway controls the dynamic localization of YAP/TAZ between nucleus and cytoplasm. | Cell Death Discovery

Fig. 1: The model of Hippo sinaling pathway in mammalian cells and the activity of Hippo sinaling pathway controls the dynamic localization of YAP/TAZ between nucleus and cytoplasm.

From: The roles of Hippo/YAP signaling pathway in physical therapy

Fig. 1

When Hippo sinaling pathway is turned off, YAP/TAZ is dephosphorylated and accumulates in the nucleus, which subsequently binds to TEADs to induce gene transcription. When the Hippo pathway is on, active LATS kinases phosphorylate YAP/TAZ, leading to cytosolic retention and degradation.

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