Fig. 2: Schematic representation of the molecular mechanism by which mechanical cues regulate YAP/TAZ.
From: The roles of Hippo/YAP signaling pathway in physical therapy
Mechanical cues, including ECM stiffness, externally applied mechanical stretch, and flow stress, control YAP/TAZ activity through Hippo dependent or independent pathways. the core kinase cascade consisting of MST1/2 and LATS1/2 responds to mechanical cues that regulate YAP/TAZ phosphorylation and localization. Mechanical cues also bypass these kinases and act through cytoplasmic and nuclear actin to regulate YAP/TAZ localization.
