Table 1 The impact of physical therapy on disease via Hippo/YAP signaling pathway.
From: The roles of Hippo/YAP signaling pathway in physical therapy
Physical therapy | Tissue (Cell) type | Signaling pathways | Effect | References |
|---|---|---|---|---|
Exercise | human cardiac myocytes C57BL/6 mice | Hippo/YAP | promote stem cell migration and inhibit cell apoptosis | [61] |
Aerobic exercise | SD rats | ELABELA-APJ-Akt/YAP | keep more cardiomyocytes alive and increase angiogenesis | [65] |
FLIPUS | murine C2C12 cells | YAP | improve the cell proliferative potential | [77] |
LIPUS | human umbilical vein endothelial cells | YAP/TAZ | initiate angiogenesis to accelerate fracture healing | [79] |
LIPUS | C3H10T1/2 mesenchymal stem cell line | YAP | suppress differentiation into mature adipocytes | [81] |
LIPUS | retinal ganglion cells mice ON crush model | YAP | protect retinal ganglion cells from loss and apoptosis | [82] |
LIPUS | rat model of periodontitis, primary human PDLCs | YAP | inhibit hPDLC apoptosis and promote autophagic degradation | [84] |
LIPUS | chondrocytes SD rants | YAP-RIPK1-NF-κB | rescue the damaged autophagy of chondrocytes | [85] |
Periodic heat stress | ectomesenchymal stem cells | YAP/TG2 | increase alkaline phosphatase activity and upregulate osteogenic-related proteins | [92] |
Cold stress | 293FT (or N2A) cells ICR pregnant mice RBM3 knockout mice | RBM3/YAP1 | rescue the brain development defect | [93] |
Cold stress | 3T3-L1 cells and HEK293T cells CAG loxp-stop-loxp-Yap mice | miR-429-YAP | improve the impaired WAT browning in middle-aged mice | [95] |
LTAP | human HaCaT cells, HDFs, NHEKs, NHEMs and murine B16F10 cells | YAP | regulate skin moisturizing and melanogenesis | [96] |
Temperature-sensitive mechanically active hydrogel | rat model with full-thickness skin wounds | YAP and MEK | reduce inflammation | [102] |
LIV | mesenchymal stem cells | YAP | restore basal nuclear YAP levels and increas the YAP nuclear shuttling | [116] |
LIESWT | sciatic nerve injury model rat Schwann cells rat perineurial fibroblasts cells | YAP/TAZ | activate SCs and regenerate injured nerve axon | [123] |
EA | SD rats | YAP | reduce apoptosis and neuroinflammation | [131] |
EA | SD rats | YAP-OPA1 | activate mitochondrial fusion function | [132] |
EA | SD rats primary microglia | Hippo/YAP | regulate microglia polarization | [133] |
