Table 2 Summary of ADP-ribosyl hydrolases.
Group | Name | Catalytic activity | Targets | Localization | |
|---|---|---|---|---|---|
ARHs family | ARH1 | De-MAR, | Protein, | Cytosol | Bacterial infection, Cancer progression |
| Â | ARH2 | Inactive | Â | Cytosol | Â |
| Â | ARH3 | De-MAR, De-PAR, De-OAADPr | Protein, dsDNA, ssRNA | Nucleus, Cytosol (mitochondria) | Genome stability, Parthanatos regulation, Antioxidant |
Macrodomain-containing family | PARG | De-MAR, De-PAR | Protein, dsDNA, ssDNA, ssRNA | Nucleus, Cytosol | DNA repair |
| Â | MacroD1 | De-MAR, De-OAADPr | dsDNA, ssRNA | Cytosol (mitochondrial) | DNA repair, cellular senescence |
| Â | MacroD2 | De-MAR, De-OAADPr | dsDNA, ssRNA | Cytosol | DNA repair, nervous disorder |
| Â | TARG1 | De-MAR, De-OAADPr | dsDNA, ssRNA | Nucleus | Insulin sensitivity |
Nudix family | NUDT9 | De-PAR | Protein | Cytosol (mitochondrial) | Energy metabolism, Calcium homeostasis |
| Â | NUDT16 | De-MAR De-PAR De-OAADPr | Protein, dsDNA, ssRNA | Nucleus, Cytosol | DNA damage repair |
