Fig. 2: Lmna KO skeletal muscle displays increased expression of p53-dependent genes. | Cell Death Discovery

Fig. 2: Lmna KO skeletal muscle displays increased expression of p53-dependent genes.

From: Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A/C-deficient mice

Fig. 2: Lmna KO skeletal muscle displays increased expression of p53-dependent genes.

A Representative image of p53 immunofluorescence in Lmna WT and Lmna KO skeletal myofibers isolated from the EDL. Note the increased levels in highly damaged myonuclei. Scale bar: 20 µm. B Quantification of relative gene expression of p53-dependent genes (Cdkn1a, Tp53inp1, Mdm2 and Gdf15) in Lmna WT and Lmna KO in the myotendinous region of the tibialis anterior muscle. (N = 8 mice; data shown as mean ± SEM; unpaired Student’s t test). C Quantification of relative gene expression of Trp53 in Lmna WT and Lmna KO skeletal muscle. (N = 8 mice; data shown as mean ± SEM; unpaired Student’s t test).

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