Fig. 3: Suppression of NUP43 hampers the progression of CRC and liver metastasis in vivo. | Cell Death Discovery

Fig. 3: Suppression of NUP43 hampers the progression of CRC and liver metastasis in vivo.

From: NUP43 promotes PD-L1/nPD-L1/PD-L1 feedback loop via TM4SF1/JAK/STAT3 pathway in colorectal cancer progression and metastatsis

Fig. 3

A, B Three shRNAs (sh-NUP43-1#, sh-NUP43-2#, and sh-NUP43-3#) were designed to silence CRC cells (MC38 and CT26) and verified by qRT-PCR and Western blotting. We used sh-NUP43-3# to downregulate NUP43. C Illustrative photos of subcutaneous tumors from both the sh-NC and sh-NUP43 groups. D, E Statistics of weight (D) and volume (E) of subcutaneous tumors in each group. F Immunohistochemical findings of NUP43, Ki-67, and TUNEL expression were seen in each group. G Illustrative visuals of liver metastases in both the sh-NC and sh-NUP43 groups. H Immunohistochemical findings of NUP43, Ki-67, and TUNEL expression were seen in each group. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.

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