Fig. 5: NUP43 facilitates the nuclear translocation of PD-L1. | Cell Death Discovery

Fig. 5: NUP43 facilitates the nuclear translocation of PD-L1.

From: NUP43 promotes PD-L1/nPD-L1/PD-L1 feedback loop via TM4SF1/JAK/STAT3 pathway in colorectal cancer progression and metastatsis

Fig. 5

A The location of PD-L1 in CRC cells (HCT116 and SW480) was studied using immunofluorescence labeling and confocal imaging. The scale bar used was 5 μm. B, C Following the separation of cells into several groups (sh-NUP43, sh-NC, Vector, NUP43), a PD-L1 Western blot analysis was conducted.ST exposure refers to a brief duration of exposure, while LT exposure refers to a prolonged duration of exposure. Lamin B1 serves as a marker for nuclear proteins, while tubulin serves as a marker for cytoplasmic proteins. D, E The cellular localization of PD-L1 was examined in each group using confocal microscopy and immunofluorescence labeling.

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