Fig. 4: Effects of ML-SI1 on cell migration, drug sensitivity and ferroptosis in breast cancer cells. | Cell Death Discovery

Fig. 4: Effects of ML-SI1 on cell migration, drug sensitivity and ferroptosis in breast cancer cells.

From: Inhibition of lysosomal TRPML1 channel eliminates breast cancer stem cells by triggering ferroptosis

Fig. 4: Effects of ML-SI1 on cell migration, drug sensitivity and ferroptosis in breast cancer cells.The alternative text for this image may have been generated using AI.

A Representative wound healing images of HCC1954 cells before and after incubation with DMSO or 10 μM ML-SI1 for 48 h. The wound was created by a straight-line scratch across the cell monolayer with a 1 mL pipette tip. The red dashed lines indicate wound edges. Scale bar = 400 μm. B Relative migration rates in A. C Cell viability assessed with a CCK-8 kit in SUM149, SUM159, and MCF cells treated with 0 μM, 10 μM, and 20 μM ML1-SI1. Viability of HCC1954 (D), SUM149 (E), SUM159 (F), and MCF7 (G) cells after 48 h treatment with DOX or DOX + 10 μM ML-SI1 as indicated. Data are presented as the means ± SEM.

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