Fig. 8: MiR-485-3p increased chemosensitivity in vivo and the correlation between DNMT3B and SLC7A11 expression in patients with pancreatic cancer. | Cell Death Discovery

Fig. 8: MiR-485-3p increased chemosensitivity in vivo and the correlation between DNMT3B and SLC7A11 expression in patients with pancreatic cancer.

From: Hypoxia-induced epigenetic regulation of miR-485-3p promotes stemness and chemoresistance in pancreatic ductal adenocarcinoma via SLC7A11-mediated ferroptosis

Fig. 8: MiR-485-3p increased chemosensitivity in vivo and the correlation between DNMT3B and SLC7A11 expression in patients with pancreatic cancer.

A Tumor formation in groups of PDAC cell lines with control or miR-485-3p overexpression after treatment with gemcitabine. The volume growth and tumor weight of subcutaneous tumors were recorded. B The levels of SOX9, SLC7A11, SOX2, and ACSL4 were assessed in different groups by IHC. Scale bar, 50 μm. C Representative IHC staining for HIF-1α, DNMT3B, and SLC7A11 in PDAC patients. CASE1 and CASE2 refer to two representative samples categorized by low and high DNMT3B expression. Scale bar, 50 μm. D The percentage of specimens with low or high SLC7A11 expression in the low or high DNMT3B expression groups. E The percentage of specimens with low or high DNMT3B and SLC7A11 expression in the low or high HIF-1α expression groups. F Graphical abstract highlighting the role of hypoxia/DNMT3B/miR-485-3p/SLC7A11 and SOX9 axis in regulating stemness and chemoresistance of PDAC cells.

Back to article page