Fig. 7: Deacetylated MDH1 and IDH1 deacetylation aggravated PANoptosis during ALF through ER stress signaling. | Cell Death Discovery

Fig. 7: Deacetylated MDH1 and IDH1 deacetylation aggravated PANoptosis during ALF through ER stress signaling.

From: Deacetylated MDH1 and IDH1 aggravates PANoptosis in acute liver failure through endoplasmic reticulum stress signaling

Fig. 7

A The expression of ER stress-related molecules BIP, ATF6, XBP1, CHOP in AML-12 cells was detected by Western blot. B Cell viability and LDH release of AML-12 cells in each group. C The expression of PANoptosis-related molecules RIPK1, GSDMD, caspase-3, MLKL, IL-18, and IL-1β in AML-12 cells was detected by Western blot. D The expression of GSDMD in AML-12 cells was detected by immunofluorescence. The results are presented as mean ± SD based on three repetitions. * compared with LPS/D-Gal group, P < 0.05; # compared with LPS/D-Gal + MDH1K118R group, P < 0.05; & compared with LPS/D-Gal + IDH1 K93R group, P < 0.05.

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