Fig. 7: USP14 deficiency attenuates neointima formation in vivo. | Cell Death Discovery

Fig. 7: USP14 deficiency attenuates neointima formation in vivo.

From: USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein

Fig. 7: USP14 deficiency attenuates neointima formation in vivo.The alternative text for this image may have been generated using AI.

A Immunofluorescence staining demonstrates GFP (green) and USP14 (red) expression in the ligated carotid of mice. B Neointima formation in the carotid arteries between the control and AAV-USP14 shRNA groups using HE staining. C Quantified intimal areas (n = 4 after 21 days). D Body weight (g) after 21 days (n = 4). E Skp2 and MMP9 expression in the ligated carotid using IHC. F HE-stained carotid is shown in the mice model of ligation after 21 days in the control and IU1 groups. G Intimal area and H body weight (g) (n = 3).

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