Fig. 8: Schematic summary. | Cell Death Discovery

Fig. 8: Schematic summary.

From: USP14 deficiency inhibits neointima formation following vascular injury via degradation of Skp2 protein

Fig. 8: Schematic summary.The alternative text for this image may have been generated using AI.

This study elucidated the function of USP14 in modulating neointima formation. USP14 is localized in SMCs and is upregulated after carotid ligation and PDGF-BB stimuli. USP14 interacts with and stabilizes Skp2 expression by preventing its degradation and subsequently moderating the expression of proliferation-related proteins (Cyclin D1 and p27) and migration protein (MMP2). The inhibition or knockdown of USP14 suppresses VSMC proliferation and decreases neointima formation.

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